On November 2, 2025, an exciting NFL matchup is set between the Buffalo Bills and the Kansas City Chiefs at Highmark Stadium in Orchard Park. The game is scheduled for a 4:25 PM start, setting the stage for what promises to be a thrilling contest.

The Kansas City Chiefs currently hold a season record of 2-2-0, ranking them second in their division and seventh in the conference with a 0.50 win percentage. They’ve scored 97 points and conceded 76, boasting a positive net point difference of 21. On the other side, the Buffalo Bills are leading their division and conference with a flawless record of 4-0-0, achieving a 1.00 win percentage. They have scored a robust 133 points, while giving up 90, leading to a net point difference of 43.

In their recent outings, the Chiefs overcame San Francisco with a 28-18 victory, accumulating 22 first downs and amassing a total of 329 yards. The Bills, meanwhile, decisively defeated Tennessee 34-10, highlighted by 315 passing yards and a strong defensive performance. Chiefs’ quarterback Patrick Mahomes and Bills’ counterpart Josh Allen showed commendable performances last week, passing for 154 and 323 yards respectively, setting the scene for a highly anticipated quarterback duel.
The looming quarterback showdown between Mahomes and Allen is pivotal. Last week, Mahomes, despite no touchdowns, maintained a passer rating of 44.37, whereas Allen executed two touchdown passes, reaching a stellar passer rating of 116.1.

The betting odds indicate a close encounter. Buffalo Bills are favored with a point spread of -2.50, and Kansas City Chiefs are closely behind at +2.50. The game total (over/under) is expected to be around 48.70, suggesting anticipation of a moderately high-scoring affair. According to moneyline bets, the Bills are slightly favored at -143, while the Chiefs stand at +121. These odds reveal that the Bills are seen as the favorites entering this game, yet only by a slender margin, promising an enthralling showdown that could tilt either way.